Publications




  • Mucosal-associated invariant T cells are functionally impaired in pediatric and young adult patients following allogeneic hematopoietic stem cell transplantation and their recovery correlates with clinical outcomes. Galaverna F, Flamini S, De Luca CD, Pili I, Boccieri E, Benini F, Quagliarella F, Rosignoli C, Rosichini M, Genah S, Catanoso M, Cardinale A, Volpe G, Coccetti M, Pitisci A, Li Pira G, Carta R, Lucarelli B, Del Bufalo F, Bertaina V, Becilli M, Pagliara D, Algeri M, Merli P, Locatelli F, Velardi E.  Haematologica. 2024 May 30. doi: 10.3324/haematol.2023.284649.
  • Thymic-Epithelial-Cell-Dependent Microenvironment Influences Proliferation and Apoptosis of Leukemic Cells. Patel SK, Zhdanovskaya N, Sergio I, Cardinale A, Rosichini M, Varricchio C, Pace E, Capalbo C, Locatelli F, Macone A, Velardi E, Palermo R, Felli MP.  Int J Mol Sci. 2024 Jan 24;25(3):1412. doi: 10.3390/ijms25031412. 
  • MYOD-SKP2 axis boosts tumorigenesis in fusion-negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting. Pomella S, Cassandri M, D'Archivio L, Porrazzo A, Cossetti C, Phelps D, Perrone C, Pezzella M, Cardinale A, Wachtel M, Aloisi S, Milewski D, Colletti M, Sreenivas P, Walters ZS, Barillari G, Di Giannatale A, Milano GM, De Stefanis C, Alaggio R, Rodriguez-Rodriguez S, Carlesso N, Vakoc CR, Velardi E, Schafer BW, Guccione E, Gatz SA, Wasti A, Yohe M, Ignatius M, Quintarelli C, Shipley J, Miele L, Khan J, Houghton PJ, Marampon F, Gryder BE, De Angelis B, Locatelli F, Rota R. Nat Commun. 2023 Dec 15;14(1):8373. doi: 10.1038/s41467-023-44130-0.
  • Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor. Algeri M, Velardi E, Spada M, Galaverna F, Carta R, Vinti L, Palumbo G, Gaspari S, Pietrobattista A, Boccieri E, Becilli M, Francalanci P, Bertaina V, Merli P, Locatelli F.  Am J Transplant. 2023 Sep;23(9):1446-1450. doi: 10.1016/j.ajt.2023.04.003. Epub 2023 Apr 13.
  • SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity. Rosichini M, Bordoni V, Silvestris DA, Mariotti D, Matusali G, Cardinale A, Zambruno G, Condorelli AG, Flamini S, Genah S, Catanoso M, Del Nonno F, Trezzi M, Galletti L, De Stefanis C, Cicolani N, Petrini S, Quintarelli C, Agrati C, Locatelli F, Velardi E.  J Allergy Clin Immunol. 2023 Apr;151(4):911-921. doi: 10.1016/j.jaci.2023.01.022. Epub 2023 Feb 8.
  • Damage-induced pyroptosis drives endog thymic regeneration via induction of Foxn1 by purinergic receptor activation. Kinsella S, Evandy CA, Cooper K, Cardinale A, Iovino L, deRoos P, Hopwo KS, Smith CW, Granadier D, Sullivan LB, Velardi E, Dudakov JA. bioRxiv. 2023 Jan 20:2023.01.19.524800. doi: 10.1101/2023.01.19.524800. Preprint.
  • Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia. Caruso S, De Angelis B, Del Bufalo F, Ciccone R, Donsante S, Volpe G, Manni S, Guercio M, Pezzella M, Iaffaldano L, Silvestris DA, Sinibaldi M, Di Cecca S, Pitisci A, Velardi E, Merli P, Algeri M, Lodi M, Paganelli V, Serafini M, Riminucci M, Locatelli F, Quintarelli C.  J Hematol Oncol. 2022 Nov 5;15(1):163. doi: 10.1186/s13045-022-01376-3.
  • Donor natural killer cells trigger production of beta-2-microglobulin to enhance post bone marrow transplant immunity. Ruggeri L, Urbani E, Chiasserini D, Susta F, Orvietani PL, Burchielli E, Ciardelli S, Sola R, Bruscoli S, Cardinale A, Pierini A, Piersma S, Pasquino S, Locatelli F, Ramarli D, Velardi E, Binaglia L, Jimenez C, Hollander G, Velardi A. Blood. 2022 Aug 5:blood.2021015297. doi: 10.1182/blood.2021015297. 
  • Signaling Crosstalks Drive Generation and Regeneration of the Thymus. Rosichini M, Catanoso M, Screpanti I, Felli MP, Locatelli F, Velardi E. Front Immunol. 2022 Jun 6;13:920306. doi: 10.3389/fimmu.2022.920306. 
  • Thymic Function and T-Cell Receptor Repertoire Diversity: Implications for Patient Response to Checkpoint Blockade Immunotherapy. Cardinale A, De Luca CD, Locatelli F, Velardi E.  Front Immunol. 2021 Nov 24;12:752042. 
  • Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signaling. Nazio F, Po A, Abballe L, Ballabio C, Diomedi Camassei F, Bordi M, Camera A, Caruso S, Caruana I, Pezzullo M, Ferraina C, Milletti G, Gianesello M, Reddel S, De Luca CD, Ceglie D, Marinelli S, Campello S, Papaleo E, Miele E, Cacchione A, Carai A, Vinci M, Velardi E, De Angelis B, Tiberi L, Quintarelli C, Mastronuzzi A, Ferretti E, Locatelli F, Cecconi F. Acta Neuropathol. 2021 
  • The role of the thymus in allogeneic bone marrow transplantation and the recovery of the peripheral T-cell compartment. Velardi, E., E. Clave, L.C.M. Arruda, F. Benini, F. Locatelli, and A. Toubert. 2021. Semin Immunopathol 43:101-117.
  • T cell regeneration after immunological injury. Velardi, E., J.J. Tsai, and M.R.M. van den Brink. 2020. Nat Rev Immunol
  • Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury. Velardi, E., J.J. Tsai, S. Radtke, K. Cooper, K.V. Argyropoulos, S. Jae-Hung, L.F. Young, A. Lazrak, O.M. Smith, S. Lieberman, F. Kreines, Y. Shono, T. Wertheimer, R.R. Jenq, A.M. Hanash, P. Narayan, Z. Lei, M.A. Moore, H.P. Kiem, M.R.M. van den Brink, and J.A. Dudakov. 2018. Nat Med 24:239-246.
  • Sex steroid ablation: an immunoregenerative strategy for immunocompromised patients. Velardi, E., J.A. Dudakov, and M.R.M. van den Brink. 2015.  Bone Marrow Transplantation 50:S77-S81.
  • Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. Velardi, E., J.J. Tsai, A.M. Holland, T. Wertheimer, V.W. Yu, J.L. Zakrzewski, A.Z. Tuckett, N.V. Singer, M.L. West, O.M. Smith, L.F. Young, F.M. Kreines, E.R. Levy, R.L. Boyd, D.T. Scadden, J.A. Dudakov, and M.R. van den Brink. 2014.  J Exp Med 211:2341-2349.